The Effect of Human Muscle-Derived Stem Cells (MDSC) and Glycine-Isoleucine-Lysine-Valine-Alanine-Valine (GIKVAV) on the Cryo-Injured Bladder of Nude Mouse
- The Effect of Human Muscle-Derived Stem Cells (MDSC) and Glycine-Isoleucine-Lysine-Valine-Alanine-Valine (GIKVAV) on the Cryo-Injured Bladder of Nude Mouse
- 이용석; 이지영; 권은비; 김희연; 조혁진; 김세웅; 황태곤; 변석수; 한동근; 이지열
- MDSC; Nude Mouse; GIKVAV; Muscles; Stem cells; Nerve regeneration
- Issue Date
- The Korean journal of urology
- VOL 50, NO 5, 480-485
- Purpose: In neurogenic bladder, both smooth muscle contraction and nerve
regeneration are very important for functional improvement. Glycineisoleucine-
lysine-valine-alanine-valine (GIKVAV) is a peptide that can
induce nerve regeneration in vivo. In this study, we evaluated bladder
function after injection of muscle-derived stem cells (MDSCs) and
GIKVAV into the cryo-injured bladder of nude mice.
Results: The contractile powers of the N, S, G, M, and GM groups were
3.58±0.27, 1.54±0.25, 1.54±0.31, 2.49±0.36, and 2.44±0.34 mN/mg, respectively,
by EFS. The contractility of the bladder muscle strip in the S and
G groups was lower than that in the N group. The contractile powers
of the M and GM groups were lower than those of the N group but greater
than those of the S and G groups. In ChAT immunohistochemical staining,
nerve regeneration was increased in the G and GM groups compared with
the S and M groups.
Conclusions: Nerve regeneration was induced by GIKVAV injection
regardless of human MDSC injection. There was no direct effect of
GIKVAV on bladder muscle contractility.
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