The Effect of Human Muscle-Derived Stem Cells (MDSC) and Glycine-Isoleucine-Lysine-Valine-Alanine-Valine (GIKVAV) on the Cryo-Injured Bladder of Nude Mouse

Title
The Effect of Human Muscle-Derived Stem Cells (MDSC) and Glycine-Isoleucine-Lysine-Valine-Alanine-Valine (GIKVAV) on the Cryo-Injured Bladder of Nude Mouse
Authors
이용석이지영권은비김희연조혁진김세웅황태곤변석수한동근이지열
Keywords
MDSC; Nude Mouse; GIKVAV; Muscles; Stem cells; Nerve regeneration
Issue Date
2009-05
Publisher
The Korean journal of urology
Citation
VOL 50, NO 5, 480-485
Abstract
Purpose: In neurogenic bladder, both smooth muscle contraction and nerve regeneration are very important for functional improvement. Glycineisoleucine- lysine-valine-alanine-valine (GIKVAV) is a peptide that can induce nerve regeneration in vivo. In this study, we evaluated bladder function after injection of muscle-derived stem cells (MDSCs) and GIKVAV into the cryo-injured bladder of nude mice. Results: The contractile powers of the N, S, G, M, and GM groups were 3.58±0.27, 1.54±0.25, 1.54±0.31, 2.49±0.36, and 2.44±0.34 mN/mg, respectively, by EFS. The contractility of the bladder muscle strip in the S and G groups was lower than that in the N group. The contractile powers of the M and GM groups were lower than those of the N group but greater than those of the S and G groups. In ChAT immunohistochemical staining, nerve regeneration was increased in the G and GM groups compared with the S and M groups. Conclusions: Nerve regeneration was induced by GIKVAV injection regardless of human MDSC injection. There was no direct effect of GIKVAV on bladder muscle contractility.
URI
http://pubs.kist.re.kr/handle/201004/37159
ISSN
0494-4747
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KIST Publication > Article
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