Urinary metabolic profiling of volatile organic compounds in acute exposed volunteers after an oil spill in Republic of Korea

Title
Urinary metabolic profiling of volatile organic compounds in acute exposed volunteers after an oil spill in Republic of Korea
Authors
이정애김민화하미나정봉철
Keywords
volatile organic compounds; oil spill; acute exposure; biomonitoring; biomarker
Issue Date
2010-05
Publisher
Biomedical chromatography : BMC
Citation
VOL 24, 562-568
Abstract
The Herbei Spirit oil spill occurred in western Korea. A large number of people who participated in the cleanup tasks of the contaminated area were exposed to crude oil component. We developed a method to monitor volatile organic compound (VOC) metabolites in urine, and evaluate the acute exposure caused by the oil spill in exposed volunteer workers (n = 100, 20.7 ± 2.1 years, mean ± SD). Acidifi ed urine samples were extracted by SPE, derivatized with trimethylsilyl, and analyzed using gas chromatography&#8211;mass spectrometry. Calibration curves were found to be linear from 3 to 1000 ng/mL (r2 > 0.993). Accuracy was over 82.4%, and precision was less than 24.8%. Using this method, the VOC metabolites, except hippuric acid, were present at higher levels in the urine samples of volunteers after cleanup work. The levels of mandelic acid (MA) and trans,trans-muconic acid (t,t-MU) were increased signifi cantly (p < 0.001). The exposure eff ect was greater in women than in men. The eff ect of smoking was analyzed in all exposed and non-exposed groups, with non-smokers showing increased MA and t,t-MU levels related to exposure. The present method was reliable to determine VOC metabolites in urine and could be useful for biomonitoring of acute exposure eff ects of VOCs.
URI
http://pubs.kist.re.kr/handle/201004/37389
ISSN
0269-3879
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE