Inhibitory effects of polyphenols isolated from Rhus verniciflua on Aldo-keto reductase family 1 B10

Title
Inhibitory effects of polyphenols isolated from Rhus verniciflua on Aldo-keto reductase family 1 B10
Authors
송대근이주영이은하정상훈노주원차광현구송이판철호
Keywords
AKR1B10; Aldo-keto reductase; Aldose reductase-like; anticancer; butein; polyphenol; Rhus verniciflua
Issue Date
2010-04
Publisher
BMB REPORTS
Citation
VOL 43, NO 4, 268-272
Abstract
Aldo-keto reductase family 1 B10 (AKR1B10) is a member of the NADPH-dependent aldo-keto reductase (AKR) superfamily, and has been considered to be a potential cancer therapeutic target. Total extract from the bark of Rhus verniciflua (Toxicodendron vernicifluum (Stokes)) showed AKR1B10 inhibitory activity. To identify the active compounds from R. verniciflua responsible for AKR1B10 inhibition, nine compounds were isolated via bioactivity-guided isolation and tested for their effects against recombinant human AKR1B10 (rhAKR1B10). Results showed that butein, isolated from the ethyl acetate fraction, was most able to inhibit rhAKR1B10. The inhibitory rate of butein against rhAKR1B10 was 42.86% at 1 μM with an IC50 value of 1.47 μM, and enzyme kinetic analysis revealed its inhibition mode to be uncompetitive.
URI
http://pubs.kist.re.kr/handle/201004/37391
ISSN
1976-6696
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KIST Publication > Article
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