ZnO nanowire biosensors for detection of biomolecular interactions in enhancement mode

Title
ZnO nanowire biosensors for detection of biomolecular interactions in enhancement mode
Authors
최아미김경원정효일이상렬
Keywords
ZnO; nanowires; biosensor; FET; streptavidin; biotin
Issue Date
2010-07
Publisher
Sensors and actuators. B, Chemical
Citation
VOL 148, NO 2, 577-582
Abstract
One dimensional oxide semiconductors have two main advantages for use in biosensors: oxide stable surfaces and high surface-to-volume ratios. In this paper, we describe a ZnO nanowire (NW) field effect transistor (FET) based biosensor for the detection of low level biomolecular interactions. ZnO NWs were grown on Au coated Al2O3 (0001) substrates by using pulsed laser (PL) deposition in an alumina tube placed inside a furnace. Field emission scanning electron microscopy (FE-SEM) images indicate that the average diameters of the ZnO NWs were about 70nm, and that the average length was about 8μm. The well crystallized structural quality of the ZnO NW was examined using photoluminescence (PL) emission measurement. The ZnO NW biosensor functionalized with biotin can easily detect streptavidin binding. The binding of streptavidin with the concentrations from 0 to 250nM resulted in the electrical current changes of up to 22.5nA. The ZnO NW biosensor could detect as low as 2.5nM of the streptavidin with 7.5nA of current increase, which implied that the sensitivity of the biosensor can be below the nM concentration of biomolecules. This novel ZnO NW biosensor has potential for sensitive, label-free, and real time detection of a wide range of biological species.
URI
http://pubs.kist.re.kr/handle/201004/37429
ISSN
0925-4005
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE