Microfluidic network-based combinatorial dilution device for high throughput screening and optimization
- Microfluidic network-based combinatorial dilution device for high throughput screening and optimization
- 이강선; 김충; 정근휘; 김태송; 강지윤; 오광욱
- combinatorial dilution; high throughput; Combinatorial device; Microfluidic network; high throughput screening; Design of experiments
- Issue Date
- Microfluidics and Nanofluidics
- VOL 8, NO 5, 677-685
- We present a combinatorial dilution device using a three-layer microfluidic network that can produce systematic variations of buffer and additive solutions in a combinatorial fashion for high throughput screening and optimization. A proof-of-concept device providing seven combinations (ABC/D, AB/D, BC/D, AC/D, A/D, B/D, and C/D) of three additive samples (A, B, and C) into a buffer solution (D) has been demonstrated. Such combinations are often used in simplex-centroid mixture DOE (design of experiments), useful techniques to minimize the experimental efforts at maximal information output with systematic variations of large-scale components. Based on mathematical and electrical modeling and computational fluid dynamic simulation, the device has been designed, fabricated, and characterized.
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