Chemiluminescence-Generating Nanoreactor Formulation for Near-Infrared Imaging of Hydrogen Peroxide and Glucose Level in vivo

Title
Chemiluminescence-Generating Nanoreactor Formulation for Near-Infrared Imaging of Hydrogen Peroxide and Glucose Level in vivo
Authors
임창근이용덕나진희오정민허송욱김광명최귀원김세훈권익찬
Keywords
glucose; hydrogen peroxide; imaging agents; nanoparticles; near-infrared chemiluminescence
Issue Date
2010-08
Publisher
Advanced functional materials
Citation
VOL 20, NO 16, 2644-2648
Abstract
Water-dispersed all-in-one nanoprobes composed of densely integrated peroxyoxalate fuel and a cyanine dye are formulated to optimize the nanoscopic chemiluminescence reaction. It is demonstrated that the chemiluminescent nanoformulation can generate bright near-infrared signal in response to external hydrogen peroxide that is biologically implicated with cell signaling and diseases. Successful imaging of endogenously overproduces hydrogen peroxide and indirect determination of glucose level in vivo with the chemiluminescent nanoprobes offers an opportunity for early diagnosis of diseases.
URI
http://pubs.kist.re.kr/handle/201004/37593
ISSN
1616-301X
Appears in Collections:
KIST Publication > Article
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