Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

Title
Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant
Authors
강석연박은정박우규김현정정대영정명은송광섭이석호서희정김민주이민우한호견손은정배애님김정민이진화
Keywords
Depression; Antidepressant; Serotonin; Piperazine; Pyrrole
Issue Date
2010-03
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 20, NO 5, 1705-1711
Abstract
Arylpiperzine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated as novel antidepressant compounds. The various analogues were efficiently prepared and bio-assayed for binding to 5-HT2A, 5-HT2C receptor, and 5-HT transporter. Based on their in vitro and in vivo activities as well as selectivity over other neurotransmitter receptors and PK profiles, 33 and 34 were identified as lead compounds. Consequently, this pyrrole series of compounds appears to be promising enough to warrant further investigation.
URI
http://pubs.kist.re.kr/handle/201004/37754
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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