Synthesis of Aminoquinazoline Derivatives and Their Antiproliferative Activities against Melanoma Cell Line

Title
Synthesis of Aminoquinazoline Derivatives and Their Antiproliferative Activities against Melanoma Cell Line
Authors
이준상남봉수김환오창현이소하조승주심태보하정미김동진태진성유경호
Keywords
Aminoquinazolines; Synthesis; Antiproliferative activity; A375 human melanoma cell line; Selectivity
Issue Date
2010-10
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 20, NO 19, 5722-5725
Abstract
The synthesis of a novel series of aminoquinazoline derivatives 1a–r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC50 = 0.006 μM) and good selectivity over HS27 fibroblast cell line.
URI
http://pubs.kist.re.kr/handle/201004/37975
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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