Induction of Chondrogenic or Osteogenic Differentiation Using Induced Pluripotent Stem (iPS) Cells for Tissue Engineering Applications

Title
Induction of Chondrogenic or Osteogenic Differentiation Using Induced Pluripotent Stem (iPS) Cells for Tissue Engineering Applications
Authors
최동훈유승권김익환한동근박귀덕
Keywords
Tissue engineering; iPS cells; differentiation; chondrogenesis; osteogenesis; PLGA; gelatin
Issue Date
2010-09
Publisher
Biomaterials Research
Citation
VOL 14, NO 3, 118-123
Abstract
Due to their enormous therapeutic potential, induced pluripotent stem (iPS) cells have emerged as the most promising source for cell-based applications in regenerative medicine. In this study, iPS cells were subject to chondrogenic and osteogenic differentiation in vitro using either fibrin gel or biodegradable poly(lactic-co-glycolic) acid (PLGA) and gelatin. As an adult stem cell, adipose-derived stem cells (ASCs) were also tested. While the iPS cells could form a colony only on the substrate of PLGA/gelatin film, ASCs were spreading and growing well on the PLGA itself as well as on the film. The cell growth rate of iPS cells was rather fast on the gelatin-coated plate. The gene expression levels of chondrogenic or osteogenic markers were notable with iPS cells, which were comparable with those of ASCs. This study indicates that iPS cells can be another useful cell source in musculoskeletal tissue engineering.
URI
http://pubs.kist.re.kr/handle/201004/37991
ISSN
1226-4601
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KIST Publication > Article
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