Induction of Chondrogenic or Osteogenic Differentiation Using Induced Pluripotent Stem (iPS) Cells for Tissue Engineering Applications
- Induction of Chondrogenic or Osteogenic Differentiation Using Induced Pluripotent Stem (iPS) Cells for Tissue Engineering Applications
- 최동훈; 유승권; 김익환; 한동근; 박귀덕
- Tissue engineering; iPS cells; differentiation; chondrogenesis; osteogenesis; PLGA; gelatin
- Issue Date
- Biomaterials Research
- VOL 14, NO 3, 118-123
- Due to their enormous therapeutic potential, induced pluripotent stem (iPS) cells have emerged as the most promising
source for cell-based applications in regenerative medicine. In this study, iPS cells were subject to chondrogenic and
osteogenic differentiation in vitro using either fibrin gel or biodegradable poly(lactic-co-glycolic) acid (PLGA) and gelatin.
As an adult stem cell, adipose-derived stem cells (ASCs) were also tested. While the iPS cells could form a colony
only on the substrate of PLGA/gelatin film, ASCs were spreading and growing well on the PLGA itself as well as on
the film. The cell growth rate of iPS cells was rather fast on the gelatin-coated plate. The gene expression levels of
chondrogenic or osteogenic markers were notable with iPS cells, which were comparable with those of ASCs. This
study indicates that iPS cells can be another useful cell source in musculoskeletal tissue engineering.
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