Screening of Medicinal Herbs for Inhibitory Activity against Protein Tyrosine Phosphatase 1B

Title
Screening of Medicinal Herbs for Inhibitory Activity against Protein Tyrosine Phosphatase 1B
Authors
이우정김수남윤구
Keywords
type 2 diabetes; obesity; protein tyrosine phosphatase 1B; medicinal herb; menthae Herba
Issue Date
2010-09
Publisher
생약학회지
Citation
VOL 41, NO 3, 227-231
Abstract
Protein tyrosine phosphatase 1B (PTP1B) is predicted to be therapeutic target in treatment of type 2 diabetes and obesity. Thus, in order to search for PTP1B inhibitors, we screened the inhibitory activity of PTP1B in the water extracts of 84 medicinal herbs. Among them, the extracts of Pini Folium, Magnoliae Cortex, Artemisiae asiaticae Herba, Schizonepetae Herba, Menthae Herba, Mume Fructus, Cimicifugae Rhizoma, and Amomi Cardamomi Fructus showed relatively significant (58-68%) inhibitory activity against PTP1B. Especially, the methylene chloride fraction of the methanol extract of Menthae Herba (81% inhibition at 30 μg/ml) showed more potent inhibitory activity against PTP1B than others.
URI
http://pubs.kist.re.kr/handle/201004/38039
ISSN
0253-3073
Appears in Collections:
KIST Publication > Article
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