Screening of Medicinal Herbs for Inhibitory Activity against Protein Tyrosine Phosphatase 1B
- Screening of Medicinal Herbs for Inhibitory Activity against Protein Tyrosine Phosphatase 1B
- 이우정; 김수남; 윤구
- type 2 diabetes; obesity; protein tyrosine phosphatase 1B; medicinal herb; menthae Herba
- Issue Date
- VOL 41, NO 3, 227-231
- Protein tyrosine phosphatase 1B (PTP1B) is predicted to be therapeutic target in treatment of type 2 diabetes and
obesity. Thus, in order to search for PTP1B inhibitors, we screened the inhibitory activity of PTP1B in the water extracts of
84 medicinal herbs. Among them, the extracts of Pini Folium, Magnoliae Cortex, Artemisiae asiaticae Herba, Schizonepetae
Herba, Menthae Herba, Mume Fructus, Cimicifugae Rhizoma, and Amomi Cardamomi Fructus showed relatively significant
(58-68%) inhibitory activity against PTP1B. Especially, the methylene chloride fraction of the methanol extract of Menthae
Herba (81% inhibition at 30 μg/ml) showed more potent inhibitory activity against PTP1B than others.
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