Determination of synthetic phosphodiesterase-5 inhibitors in adulterate supplements using liquid chromatography-high resolution mass spectrometry (LTQ/Orbitrap)

Title
Determination of synthetic phosphodiesterase-5 inhibitors in adulterate supplements using liquid chromatography-high resolution mass spectrometry (LTQ/Orbitrap)
Authors
김호준전병욱김진영인문교권오승진창배이재익
Issue Date
2010-08
Publisher
2010 한국질량분석학회 여름정기학술대회
Abstract
In recent years, dietary supplements, herbal medicines and counterfeit medications containing the phosphodiesterase-5 inhibitor ( PDE5-I) for erectile dysfunction (ED) are increasing all over the world. It is well known that analysis of the contents of the adulterated PDE5-Is shows inconsistent doses of active pharmaceutical ingredients and alterna tive or un-labeled ingredients. Therefore, it is very important to both identify and quantify the active ingredient. In this study, the liquid chromatography-high resolution mass spectrometry (LTQ/Orbitrap) method has been applied for the simultaneous determination and identification of nine most commonly adulterated PDE5-Is including sildenafil, tadarafil, vardenafil and their structural analogues (homosildenafil, hongdenafil, hydroxy homosildenafil, udenafil, pseudovardenafil and amino tadalafil). The method has been successfully applied to the analysis of practical samples of seven adulterated supplements and medications.
URI
http://pubs.kist.re.kr/handle/201004/38173
Appears in Collections:
KIST Publication > Conference Paper
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