Synthesis of MPEP derivatives as mGluR modulator
- Synthesis of MPEP derivatives as mGluR modulator
- 이지연; 강순방; 정낙철; 김유승; 금교창
- MPEP; Pain; mGluR
- Issue Date
- 대한화학회 제106회 총회 및 학술발표회 전자 논문집
- VOL 106, MEDLP-49
- Glutamate is the predominant excitatory neurotransmitter in the brain and activates two major receptor
classes: the ionotropic glutamate(iGluR) and the metabotropic glutamate receptors (mGluR). mGluRs
typically play a regulatory role on fast glutamatergic effects by modulating the ion channel activity and/or
neurotransmitter release. And there are eight subtypes of mGluR (mGluR 1-8). Among them, mGluR5's
over stimulation has been implicated in numerous CNS disorders.2-methyl-6-(phenylethynyl)pyridine
(MPEP) is well known potent and selective noncompetitive mGluR5 antagonist. So we, in an attempt to
develop novel mGluR5 antagonists as potential therapeutic agents for neuropathic pain, prepared a series
of MPEP derivatives.
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