Potential PET Imaging Agents for Early Diagnosis of Alzheimer’s Disease
- Potential PET Imaging Agents for Early Diagnosis of Alzheimer’s Disease
- 김영수; 김동진
- 알츠하이머; alzheimer; 치매; dementia; 조기진단; PET; amyloid; 아밀로이드
- Issue Date
- World Molecular Imaging Congress 2010
- Alzheimer’s disease (AD) is a neurodegenerative brain disorder accompanying
progressive memory loss and decline of cognitive functions. At present, clinical diagnosis of AD is
performed via mental status tests, physical exam, diagnostic tests, neurological exam, and brain imaging.
In this study novel chemical probes for beta-amyloid-specific binding agents is described. Twelve
compounds were synthesized and evaluated via a competitive binding assay with [(125)I]TZDM against
beta-amyloid 1-42 (Abeta42) aggregates. Two new [(18)F]-labeled isoindole derivatives were synthesized
and evaluated as potential beta-amyloid imaging probes based on the in vivo pharmacokinetic profiles. The
preliminary results suggest that these probes are promising positron emission tomography (PET) imaging
probes for studying accumulation of Abeta fibrils in the brains of AD patients.
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