Potential PET Imaging Agents for Early Diagnosis of Alzheimer’s Disease

Title
Potential PET Imaging Agents for Early Diagnosis of Alzheimer’s Disease
Authors
김영수김동진
Keywords
알츠하이머; alzheimer; 치매; dementia; 조기진단; PET; amyloid; 아밀로이드
Issue Date
2010-09
Publisher
World Molecular Imaging Congress 2010
Abstract
Alzheimer’s disease (AD) is a neurodegenerative brain disorder accompanying progressive memory loss and decline of cognitive functions. At present, clinical diagnosis of AD is performed via mental status tests, physical exam, diagnostic tests, neurological exam, and brain imaging. In this study novel chemical probes for beta-amyloid-specific binding agents is described. Twelve compounds were synthesized and evaluated via a competitive binding assay with [(125)I]TZDM against beta-amyloid 1-42 (Abeta42) aggregates. Two new [(18)F]-labeled isoindole derivatives were synthesized and evaluated as potential beta-amyloid imaging probes based on the in vivo pharmacokinetic profiles. The preliminary results suggest that these probes are promising positron emission tomography (PET) imaging probes for studying accumulation of Abeta fibrils in the brains of AD patients.
URI
http://pubs.kist.re.kr/handle/201004/38277
Appears in Collections:
KIST Publication > Conference Paper
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