An efficient and enantioselective total synthesis of naturally occurring L-783277

Title
An efficient and enantioselective total synthesis of naturally occurring L-783277
Authors
최환근손정범박동식함영진하정미심태보
Issue Date
2010-09
Publisher
Tetrahedron letters: the international organ for the rapid publication of preliminary communications in organic chemistry
Citation
VOL 51, NO 38, 4942-4946
Abstract
Naturally occurring L-783277 which belongs to 14-membered resorcylic acid lactones (RALs) turned out to be a potent kinase inhibitor against MEK (MAP kinase kinase). We successfully accomplished efficient and enantioselective total synthesis of L-783277 based on convergent assembly of one aromatic unit and two chiral building blocks with efficient orthogonal protection-deprotection strategy. Three key steps composed of olefin cross metathesis, addition of acetylene derivative to aldehyde, and Yamaguchi macrolactonization were subsequently employed to construct the framework of L-783277. The optical rotation value of L-783277 is for the first time presented in this Letter.
URI
http://pubs.kist.re.kr/handle/201004/38282
ISSN
0040-4039
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KIST Publication > Article
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