Magnetite-nanoparticle-encapsulated pH-responsive polymeric micelle as an MRI probe for detecting acidic pathologic areas

Title
Magnetite-nanoparticle-encapsulated pH-responsive polymeric micelle as an MRI probe for detecting acidic pathologic areas
Authors
Guang Hui GaoGeun Ho ImMin Sang KimJae Won LeeJehoon Yang전혜성Jung Hee LeeDoo Sung Lee
Issue Date
2010-06
Publisher
Small
Citation
VOL 6, NO 11, 1201-1204
Abstract
Nanometer-sized particles are increasingly used for biomedical applications,[1] as polymeric micelles to carry hydrophobic imaging markers and/or drugs for disease diagnosis and therapy.[2] Usually, these polymeric micelles in an aqueous medium are composed of a hydrophobic core and a hydrophilic corona, sometimes conjugated with active-targeting ligands (e.g., antibody, peptides, nucleic acids) that can target the biomarker of a disease.[2a–c]Onthe other hand, some polymeric micelles alone, not conjugated with a targeting ligand, can also target the pathologic tissue by a stimuli-response mechanism, with which pH, temperature, or redox can be a stimulus condition.[3] In this context, a pH-responsive polymeric micelle is utilized to be reactive in an acidic-pH environment, in which it is then dissolved. We envisioned that if we encapsulate magnetite nanoparticles (Fe3O4), which are frequently used as a contrast agent for magnetic resonance imaging (MRI), into the pH-responsive polymeric micelle, the resulting Fe3O4- nanoparticle-loaded pH-responsive polymeric micelle could be used as a contrast agent for MRI to target and, simultaneously, image the pH-stimuli tissue, such as cancerous tissue. Herein, we report a facile and powerful pH-responsive polymeric micelle that can well encapsulate Fe3O4 nanoparticles, and its potential applications in medicine for diagnostic imaging of acidic pathologic areas.
URI
http://pubs.kist.re.kr/handle/201004/38298
ISSN
1613-6810
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KIST Publication > Article
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