Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits

Title
Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits
Authors
안찬묵박병곤우호범함정엽신운섭이석준
Keywords
vascular disease; vasodilatation effect; Curcumin
Issue Date
2010-08
Publisher
240th ACS National Meeting
Abstract
In order to discover novel small vasodilatory mols. for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compds. 12 and 20 effectively dilated the basilar artery of white rabbits.
URI
http://pubs.kist.re.kr/handle/201004/38405
Appears in Collections:
KIST Publication > Conference Paper
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