Synthesis of a pH-Sensitive PEO-Based Block Copolymer and its Application for the Stabilization of Iron Oxide Nanoparticles

Title
Synthesis of a pH-Sensitive PEO-Based Block Copolymer and its Application for the Stabilization of Iron Oxide Nanoparticles
Authors
김근석김태환최진철이재열하상수유현오황승상류경남김형중김정안
Keywords
pH-Sensitive; amphiphilic; Block copolymer; Iron Oxide Nanoparticle; MR imaging contrast agent; superparamagnetic iron oxide nanoparticles; reversible addition-fragmentation chain transfer
Issue Date
2010-05
Publisher
Macromolecular chemistry and physics
Citation
VOL 211, NO 10, 1127-1136
Abstract
PEO-based amphiphilic block copolymers that exhibit a pH responsive phase transition behavior are synthesized. The amphiphilic block copolymers show sharp phase transitions in the physiological pH (7.2) range of aqueous media. The block copolymers were efficient stabilizers for the preparation of superparamagnetic iron oxide nanoparticles in aqueous media. The resulting iron oxide nanoparticles in the size range of 5–30nm showed a relatively good T*2 2 image on the basis of the results on their phantom test. All the materials were characterized by the combination of 1H NMR spectroscopy, size exclusion chromatography, UV/visible spectroscopic analysis, magnetization, transmission electron microscopy, electron diffraction, and X-ray diffraction pattern analysis.
URI
http://pubs.kist.re.kr/handle/201004/38474
ISSN
1022-1352
Appears in Collections:
KIST Publication > Article
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