Synthesis and antiproliferative activity of pyrrolo[3,2-b]pyridine derivatives against melanoma

Title
Synthesis and antiproliferative activity of pyrrolo[3,2-b]pyridine derivatives against melanoma
Authors
김희진정명호김환엘가말심태보이소하홍준희하정미조정혁최정훈유경호오창현
Keywords
Pyrrolo[3,2-b]pyridine; A375; Antiproliferative activity; Melanoma; HS 27
Issue Date
2010-01
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 20, NO 1, 413-417
Abstract
Synthesis of a new series of diarylureas and amides having pyrrolo[3,2-b]pyridine scaffold is described. Their in vitro antiproliferative activity against human melanoma cell line A375 and HS 27 human fibroblast cell line was tested and the effect of substituents on the pyrrolo[3,2-b]pyridine was investigated. The newly synthesized compounds, except meta-substituted derivatives (Ij–k and Iv–w), generally showed superior or similar activity against A375 to Sorafenib. Among all of these derivatives, compounds Ir and It having 5-benzylamide substituted 4'-amide moieties showed the most potent antiproliferative activity against A375.
URI
http://pubs.kist.re.kr/handle/201004/38565
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE