Channel-Mediated Tonic GABA Release from Glia
- Channel-Mediated Tonic GABA Release from Glia
- 이수정; 윤보은; Ken Berglund; 오수진; 박형주; 신희섭; 조지어거스틴; 이창준
- bestrophin; calcium; anion; Bergmann glia; lamellar astrocyte; cerebellum; granule cell
- Issue Date
- VOL 330, NO 6005, 790-796
- Synaptic inhibition is based on both tonic and phasic release of the inhibitory transmitter
γ-aminobutyric acid (GABA). Although phasic GABA release arises from Ca2+-dependent
exocytosis from neurons, the mechanism of tonic GABA release is unclear. Here we report that
tonic inhibition in the cerebellum is due to GABA being released from glial cells by permeation
through the Bestrophin 1 (Best1) anion channel. We demonstrate that GABA directly permeates
through Best1 to yield GABA release and that tonic inhibition is eliminated by silencing of
Best1. Glial cells express both GABA and Best1, and selective expression of Best1 in glial cells,
after preventing general expression of Best1, fully rescues tonic inhibition. Our results
identify a molecular mechanism for tonic inhibition and establish a role for interactions
between glia and neurons in mediating tonic inhibition.
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