Comparison of D-[18F]FMAU and L-[18F]FMAU as PET Imaging Agents for HSV1-TK Gene Expression

Title
Comparison of D-[18F]FMAU and L-[18F]FMAU as PET Imaging Agents for HSV1-TK Gene Expression
Authors
문병석조남현이교철엘가말안광일홍서희최태현최원경박진헌조정혁천기정오창현
Keywords
HSV1-TK; L-[18F]FMAU; PET imaging; MicroPET; D-[18F]FMAU
Issue Date
2010-11
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 31, NO 11, 3309-3312
Abstract
D-[18F]FMAU and L-[18F]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe. D-[18F]FMAU and L-[18F]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice. Their cellular uptake profiles were also compared using MCA and MCA-TK cell lines. D-[18F]FMAU demonstrated higher cellular uptake and higher accumulation in MCA-TK tumor regions than L-[18F]FMAU. On the other hand, L-[18F]FMAU showed higher MCA-TK/MCA ratio of %ID/g than that of D-[18F]FMAU. L-[18F]FMAU can be utilized as a good candidate for HSV1-TK PET imaging. It can be used for antiviral drug evaluation.
URI
http://pubs.kist.re.kr/handle/201004/38634
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
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