Beneficial Effect of Sulfonated PEO-grafted Polyurethanes on Calcification and Lipid Adsorption of Vascular Implants

Title
Beneficial Effect of Sulfonated PEO-grafted Polyurethanes on Calcification and Lipid Adsorption of Vascular Implants
Authors
최지연이봉수박귀덕한동근박기동김영하
Keywords
PEO; Calcification; Vascular; Implants
Issue Date
2010-11
Publisher
Macromolecular research
Citation
VOL 18, NO 11, 1133-1136
Abstract
Polyurethane (PU) has been used in many industrial applications as well as in clinics for a wide variety of biomedical applications, because of its good physical properties and physiological acceptability.1,2 However, its performance for a long-term implantation is hampered, due mainly to the incomplete blood compatibility. Moreover, PU is degraded due to the leakage of additive and low molecular weight fraction, depolymerization, bond and side group change, and residual stress.3 For the improvement of the biocompatibility and biostability of PU, numerous attempts have been made via surface and bulk modifications.4-6 Meanwhile, calcification, defined as the deposition of calcium compounds such as calcium phosphate, causes the loss of the flexibility of biomaterials, ultimately resulting in their mechanical failure and degradation.7 Therefore, the prevention of such phenomenon is critical for a long-term safety so that many investigations have been carried out minimize biomaterial calcification.8
URI
http://pubs.kist.re.kr/handle/201004/38646
ISSN
1598-5032
Appears in Collections:
KIST Publication > Article
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