Synthesis of O-Carboxylated Low Molecular Chitosan with Azido Phenyl Group: Its Application for Adhesion Prevention

Title
Synthesis of O-Carboxylated Low Molecular Chitosan with Azido Phenyl Group: Its Application for Adhesion Prevention
Authors
나하나김광일한재홍이재관손태일한동근Yoshihiro Ito송광섭장의찬
Keywords
O-Carboxylated; Prevention; Chitosan; Phenyl; photo-immobilization; anti-adhesive agent; drugeluting
Issue Date
2010-10
Publisher
Macromolecular research
Citation
VOL 18, NO 10, 1001-1007
Abstract
A water-soluble photo-reactive chitosan derivative was synthesized as a novel anti-adhesive agent by combining low molecular O-carboxymethyl chitosan and photo-reactive N-(4-azidobenzoyloxy) succinimide. Photoreactive low molecular O-carboxymethyl chitosan was analyzed by Fourier transform infrared spectroscopy (FTIR) and proton nuclear resonance spectroscopy (1H NMR). Photo-immobilization of the polymer was confirmed using photo-mask and the degree of cross-linking was measured from the immobilized dried weight. The cytotoxicity of the photo-reactive low molecular O-carboxymethyl chitosan was confirmed by a MTT assay. In vivo animal study was performed to identify the synthetic material for antiadhesive effect. Furthermore, the protein release test that was performed to apply it as a drug-eluting anti-adhesive agent after bovine serum albumin (BSA), was immobilized to the photoreactive polymer. Because photo-reactive low molecular O-carboxymethyl chitosan has high water solubility as well as non-cytotoxicity and photoimmobilization, it may a suitable material for making drug-eluting antiadhesive agents.
URI
http://pubs.kist.re.kr/handle/201004/38647
ISSN
1598-5032
Appears in Collections:
KIST Publication > Article
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