Ultrasonic coating and controlled release behavior of sirolimus-loaded biodegradable polymers containing various additives for stent
- Ultrasonic coating and controlled release behavior of sirolimus-loaded biodegradable polymers containing various additives for stent
- 김진향; 이봉수; 최지연; 강종희; 박귀덕; 한동근
- Issue Date
- 2010 한국고분자학회 추계학술대회
- CypherTM stent fabricated from sirolimus (SRL) and non-biodegradable polymers, poly(ethykene-co-vinyl acetate) (PEVA) and poly(n-buryl methacrylate) (OBMA), has used for inhibiting proliferation of smooth muscle cells (SMCs) induced from injury after stent implantation. Little work has been reported about the fabrication of SRL-loaded stent coated with biodegradable polymers (e.g. PDLLA, PLLA, and PLGA) and the behavior of drug-release profile from the stent. The reaction mechanism of SRL is explained that SRL combiened with FK506-binding protein stops the late G1 phase of cell cycle, resulting in inhibiting the proliferation of SMCs. This study aims to understand the release kinetics of SRL from biodegradable polymers containing some additives such as PEG-derivatives, so the solution of SRL-loaded polymer was coated on stainless steel(SS) by ultrasonic spray. The coating urface of SS was characterized with SEM and their drug-release kinetics was analyzed with HPLC.
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