Identification of Post-generation Effect of 3,4-methylenedioxymethamphetamine on the mouse brain by large-scale Gene Expression Analysis

Title
Identification of Post-generation Effect of 3,4-methylenedioxymethamphetamine on the mouse brain by large-scale Gene Expression Analysis
Authors
은정우곽승준노지헌정광화김정규배현진사홍건류재천안영민박원상이정영이규식남석우
Keywords
3,4-methylenedioxymethamphetamine; brain; Gene Expression; MDMA; Neurotoxicity; Offspring
Issue Date
2010-05
Publisher
Toxicology letters
Citation
VOL 195, NO 1, 60-67
Abstract
The compound 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a synthetic, psychoactive drug chemically similar to the stimulant methamphetamine and the hallucinogen mescaline. Accumulated data has revealed potential toxic effects associated with MDMA on brain serotonin and dopamine neurons in animal models. However, the relevance of these adverse effects on prenatal exposure to this drug remains unknown. In this study, we demonstrated that prenatal (F0) exposure to MDMA caused permanent large-scale transcriptional changes in the brains of the offspring (F1), especially in the cerebral cortex, by gene expression profiling analysis. The expression analysis of the brain of F1 pups, after maternal ingestion of MDMA (20 mg/kg MDMA), revealed significant transcriptional changes in both male and female pups. Supervised analysis resulted in the identification of 804 outlier genes in males and 1784 outlier genes in females as MDMA-associated genes in the F1 generation. Most of the functional categories of genes, among the outlier genes, were intracellular signaling pathways, including the MAPK signaling pathway, Wnt signaling pathway, and neuroactive ligand–receptor interaction pathway. Although these genes were affected byMDMAexposure in utero, their association with brain dysfunction requires further investigation. The results of this study suggest that prenatal MDMA exposure may affect the developing brain.
URI
http://pubs.kist.re.kr/handle/201004/38762
ISSN
0378-4274
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KIST Publication > Article
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