Lead Optimization of Novel Triazolyl Disulfide Derivatives as a 7-Keto-8-aminopelargonic Acid Synthase Inhibitor

Title
Lead Optimization of Novel Triazolyl Disulfide Derivatives as a 7-Keto-8-aminopelargonic Acid Synthase Inhibitor
Authors
한민수남기달한호규황인택이동희
Keywords
농약; 제초제; KAPAS; triazole; disulfide
Issue Date
2010-10
Publisher
Internatioanl Symposium on Pesticide 2010
Citation
, 137-137
Abstract
KAPAS (7-keto-8-aminopelargonic acid synthase) relates to a biotin biosynthesis pathway and is a emerging potential new herbicide target. Exploration of new small molecules against KAPAS biological pathway contributes to development of new herbicide as well as validation of the mode of action. We select a new triazolyl disulfide from our indigenous chemical library by in vitro screening. Here, we report lead optimization process through in vivo screening and synthetic route of the derivatives.
URI
http://pubs.kist.re.kr/handle/201004/38775
Appears in Collections:
KIST Publication > Conference Paper
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