Attenuation of β-amyloid-induced neuroinflammation by KHG21834 in vivo
- Attenuation of β-amyloid-induced neuroinflammation by KHG21834 in vivo
- 김은아; 한호규; 김태우; 최수영; 조성우
- Alzheimer's disease; Beta-amyloid; KHG21834; Microglia; Neuroinflammation
- Issue Date
- BMB REPORTS
- VOL 43, NO 6, 413-418
- Beta-Amyloid (Aβ)-induced neuroinflammation is one of the
key events in the development of neurodegenerative disease.
We previously reported that KHG21834, a benzothiazole derivative,
attenuates Aβ-induced degeneration of cortical and
mesencephalic neurons in vitro. In the present work, we show
that KHG21834 reduces Aβ-mediated neuroinflammation in
brain. In vivo intracerebroventricular infusion of KHG21834
leads to decreases in the numbers of activated astrocytes and
microglia and level of proinflammatory cytokines such as interleukin-
1β and tumor necrosis factor-α induced by Aβ in the
hippocampus. This suppression of neuroinflammation is associated
with decreased neuron loss, restoration of synaptic dysfunction
biomarkers in the hippocampus to control level, and
diminished amyloid deposition. These results may suggest the
potential therapeutic efficacy of KHG21834 for the treatment
of Aβ-mediated neuroinflammation.
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