Attenuation of β-amyloid-induced neuroinflammation by KHG21834 in vivo

Title
Attenuation of β-amyloid-induced neuroinflammation by KHG21834 in vivo
Authors
김은아한호규김태우최수영조성우
Keywords
Alzheimer's disease; Beta-amyloid; KHG21834; Microglia; Neuroinflammation
Issue Date
2010-06
Publisher
BMB REPORTS
Citation
VOL 43, NO 6, 413-418
Abstract
Beta-Amyloid (Aβ)-induced neuroinflammation is one of the key events in the development of neurodegenerative disease. We previously reported that KHG21834, a benzothiazole derivative, attenuates Aβ-induced degeneration of cortical and mesencephalic neurons in vitro. In the present work, we show that KHG21834 reduces Aβ-mediated neuroinflammation in brain. In vivo intracerebroventricular infusion of KHG21834 leads to decreases in the numbers of activated astrocytes and microglia and level of proinflammatory cytokines such as interleukin- 1β and tumor necrosis factor-α induced by Aβ in the hippocampus. This suppression of neuroinflammation is associated with decreased neuron loss, restoration of synaptic dysfunction biomarkers in the hippocampus to control level, and diminished amyloid deposition. These results may suggest the potential therapeutic efficacy of KHG21834 for the treatment of Aβ-mediated neuroinflammation.
URI
http://pubs.kist.re.kr/handle/201004/38780
ISSN
1976-6696
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KIST Publication > Article
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