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dc.contributor.author최승혜-
dc.contributor.author최귀원-
dc.contributor.author권익찬-
dc.contributor.author황광연-
dc.contributor.author안형준-
dc.date.accessioned2015-12-03T00:34:18Z-
dc.date.available2015-12-03T00:34:18Z-
dc.date.issued201010-
dc.identifier.citation, 401-401-
dc.identifier.other33891-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/38817-
dc.description.abstractCaged proteins are macromolecules exhibiting a self-assembled nanoplatform that can be used for detection of biomolecule. We present here the strategy to image apoptotic cells using a nanoplatform of caged protein. For that purpose, cage protein was genetically modified to have two abilities, real-time imaging of apoptosis and cellualr uptake. A high ratio of target peptides to cage formed from self-assembling of cage subints resulted in increase of fluorescence signals per a probe particle, and our cage probe was well cell-permeable and exceedingly biocompatible. We demonstrated that cege probe was specifically cleaved by effector caspase in cell-free conditions, and also finally apoptotic events were imaged real-timely in living cells. Our strategy provides an application to imaging and sensing of other specific protease activities.-
dc.publisherThe 10th Conference of the Asia Crystallographic Association-
dc.subject분자영상-
dc.subject케이지 단백질-
dc.subject세포사멸-
dc.subject플래폼 기술-
dc.subject프로브-
dc.titleProtein cages provide a platform of cell-permeable and biocompatible imaging probe in living cells-
dc.typeConference Paper-
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