Real Time Imaging of Apoptosis with a Polymeric Nanoprobes in Live Cells and Animals

Title
Real Time Imaging of Apoptosis with a Polymeric Nanoprobes in Live Cells and Animals
Authors
이상민이슬기최기영정서영Xiaoyuan Chen최귀원권익찬김광명
Issue Date
2010-09
Publisher
World Molecular Imaging Conference
Abstract
We report a new apoptosis nanoprobe (Apo‐NP) designed based on a polymer nanoparticle platform. This simple one‐step technique is capable of boosting fluorescence signals upon apoptosis in living cells, enabling real‐time imaging of apoptosis in single cells and in vivo. The Apo‐NP efficiently delivers chemically‐labeled, dualquenched caspase‐3‐sensitive fluorogenic peptides into cells, allowing caspase‐3‐dependent strong fluorescence amplification to be imaged in apoptotic cells in real‐time and at high resolution. The design platform of the Apo‐NP is flexible and can be fine‐tuned for a wide array of applications such as identification of caspase‐related apoptosis in pathologies and for monitoring therapeutic efficacy of apoptotic drugs in cancer treatment.
URI
http://pubs.kist.re.kr/handle/201004/38838
Appears in Collections:
KIST Publication > Conference Paper
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE