Real Time Imaging of Apoptosis with a Polymeric Nanoprobes in Live Cells and Animals
- Real Time Imaging of Apoptosis with a Polymeric Nanoprobes in Live Cells and Animals
- 이상민; 이슬기; 최기영; 정서영; Xiaoyuan Chen; 최귀원; 권익찬; 김광명
- Issue Date
- World Molecular Imaging Conference
- We report a new apoptosis nanoprobe (Apo‐NP) designed based on a polymer nanoparticle platform. This simple one‐step technique is capable of boosting fluorescence
signals upon apoptosis in living cells, enabling real‐time imaging of apoptosis in single cells and in vivo. The Apo‐NP efficiently delivers chemically‐labeled, dualquenched
caspase‐3‐sensitive fluorogenic peptides into cells, allowing caspase‐3‐dependent strong fluorescence amplification to be imaged in apoptotic cells in real‐time
and at high resolution. The design platform of the Apo‐NP is flexible and can be fine‐tuned for a wide array of applications such as identification of caspase‐related
apoptosis in pathologies and for monitoring therapeutic efficacy of apoptotic drugs in cancer treatment.
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