Glycol chitosan nanoparticle for in vivo cancer imaging and therapy
- Glycol chitosan nanoparticle for in vivo cancer imaging and therapy
- 나진희; 구희범; 박재형; 권익찬; 정서영; 김광명
- Issue Date
- The 3rd International Conference on multifunctional materials and structures: MFMS
- , 55-55
- Chitosan and its dehvatives have been widely used for safe and effective drugdelivery systems because of its unique chemical and biological characters. When thehydrophobic moiety is conjugated to a chitosan molecule, it may form self-assemblednanoparticles in aqueous condition. Among them, glycol chitosan nanoparticle has shown itsspecial ability of large accumulation in tumor tissue than other organs when injectedintravenously, and it enables various applications in many papers. In the aqueous state, theywere stable in biological conditions for at least 1 week and their critical aggregationconcentration was lower than those of low molecular weight surfactants. Recent studiesshowed evidence that these glycol chitosan nanoparticles are a promising tool for effectivetransport and delivery ofimaging moieties and therapeutic drugs.
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