Glycol chitosan nanoparticle for in vivo cancer imaging and therapy

Title
Glycol chitosan nanoparticle for in vivo cancer imaging and therapy
Authors
나진희구희범박재형권익찬정서영김광명
Issue Date
2010-09
Publisher
The 3rd International Conference on multifunctional materials and structures: MFMS
Citation
, 55-55
Abstract
Chitosan and its dehvatives have been widely used for safe and effective drugdelivery systems because of its unique chemical and biological characters. When thehydrophobic moiety is conjugated to a chitosan molecule, it may form self-assemblednanoparticles in aqueous condition. Among them, glycol chitosan nanoparticle has shown itsspecial ability of large accumulation in tumor tissue than other organs when injectedintravenously, and it enables various applications in many papers. In the aqueous state, theywere stable in biological conditions for at least 1 week and their critical aggregationconcentration was lower than those of low molecular weight surfactants. Recent studiesshowed evidence that these glycol chitosan nanoparticles are a promising tool for effectivetransport and delivery ofimaging moieties and therapeutic drugs.
URI
http://pubs.kist.re.kr/handle/201004/38846
Appears in Collections:
KIST Publication > Conference Paper
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