IRINOTECAN-LOADED NANOPARTICLES BASED ON HYALURONIC ACID FOR TUMOR IMAGING AND THERAPY

Title
IRINOTECAN-LOADED NANOPARTICLES BASED ON HYALURONIC ACID FOR TUMOR IMAGING AND THERAPY
Authors
최기영최귀원정서영박재형김광명
Issue Date
2010-05
Publisher
Controlled Release Society
Abstract
Theranostic nanoparticles based on hyaluronic acid (HA-NPs) were successfully synthesized. Biodistribution and tumor targeting characteristics of HA-NPs were evaluated with NIRF imaging techniques. Pegylated HA nanoparticles (HA-NP-Ps) were applied to tumor imaging and therapy. It was demonstrated that the HA-NPs could deliver anti-cancer drugs and release the drugs at disease sites, resulting in increased therapeutic efficacy and reduced side effects. This system can be used as a platform technology to detect and treat various tumors.
URI
http://pubs.kist.re.kr/handle/201004/38847
Appears in Collections:
KIST Publication > Conference Paper
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