Biocompatible Gold Nanoparticles for Liver-Specific CT Imaging
- Biocompatible Gold Nanoparticles for Liver-Specific CT Imaging
- 선인철; 나진희; 최귀원; 권익찬; 안철희; 김광명
- gold nanoparticle; imaging; CT; liver targeting; surface modification
- Issue Date
- The World Molecular Imaging Congress
- We developed a new method of encapsulating gold nanoparticles (AuNP) with biocompatible polymers. The stability and biocompatibility of AuNP were significantly enhanced due to the existence of polymer. Bio-distribution and tissue targeting properties were able to be controlled by changing polymers on the surface of AuNP. A different aspect of accumulation of AuNP in the tissue according to the surface property was observed. This targeting property was applied as a tissue specific CT contrast agent because X-ray absorption of concentrated AuNP is higher than that of iodine. CT images of tissues were acquired from micro-CT and the contrast enhancement was achieved using polymer-coated AuNP when they compared to one using commercial iodine based CT contrast agent. Those polymer coated AuNPs were characterized with TEM, UV-vis and zeta-potential measurement. Biocompatible AuNPs showed low toxicity, prolonged stability and enhanced contrast, which is suitable for the biomedical application such as molecular imaging probes
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