Development of Superparamagnetic Iron Oxide Nanoparticles for NIRF/MRI Multi Modal Imaging

Development of Superparamagnetic Iron Oxide Nanoparticles for NIRF/MRI Multi Modal Imaging
iron oxide; nanoparticle; MRI; multi modal; imaging; fluorescence
Issue Date
The World Molecular Imaging Congress (WMIC)
During the past decades, various nanostructures have been exploited and successfully employed as molecular imaging probes for disease detection. Superparamagnetic iron oxide nanoparticles (SPIONs) with appropriate surface chemistry are one of the famous candidates for numerous biomedical applications such as a contrast enhancing agent of magnetic resonance imaging (MRI), tissue repair, immunoassay, hyperthermia, drug delivery and cell separation. However, in vivo application of SPIONs is challenged by stability problems because of their hydrophobic surface, insufficient accumulation and retention within tumors due to limited specificity to the target, and an inability to traverse biological barriers. Therefore, numerous SPIONs with biocompatible surface chemistry have been developed for overcoming these problems. Recently, imaging probes have several imaging modalities are the focus of researchers in biomedical field, because single imaging modality has limitations to allow overall structural, functional, and molecular information. Since each imaging modality differs from another in terms of spatial and temporal resolution, anatomical and molecular details and imaging depth, it is advantageous to apply multiple complimentary imaging modalities for faster and more accurate prognosis on many occasions. Here, we describe the preparation of biocompatible multi functional SPIONs to combine MRI and near-infrared fluorescence (NIRF) imaging for cancer diagnosis using simple coating and coupling methods. Chemically modified biocompatible polymer with enhanced adhesive ability to nanoparticles was used as a biocompatible stabilizer for SPIONs and NIRF organic dyes were conjugated to polymer coating layer for optical imaging. The nanoprobe shows remarkable cancer specific NIRF and MR images. With the conjugation of various targeting ligands and the flexible conjugation chemistry for alternative diagnostic and therapeutic ag
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