Biocompatible Materials Coated Superparamagnetic Iron Oxide Nanoparticles for NIRF/MRI Multi Modal Cancer Imaging
- Biocompatible Materials Coated Superparamagnetic Iron Oxide Nanoparticles for NIRF/MRI Multi Modal Cancer Imaging
- 차의준; 선인철; 김영일; 김광명; 권익찬; 안철희
- iron oxide; nanoparticle; MRI; multi modal; imaging; fluorescence; molecular imaging
- Issue Date
- 한국고분자학회 추계학술대회
- The combination of several imaging modalities such as CT, PET, MRI, and optical imaging represents complementary imaging information about anatomy and molecular function of human body in disease diagnosis. Especially, anatomical imaging modalities, such as MRI and CT, and functional imaging such as PET and optical imaging were combined for overcoming the limitation of single modal imaging.
Optical imaging is a well-established imaging technique for biologic information on a molecular level. However, optical imaging has limitation such as deficient anatomic information and relatively poor penetration depth. In contrast, MRI gives the ability to follow anatomic 3D images with high spatial resolution. On the other hands, it is difficult to obtain biologic information, such as protein activity and existence of specific molecules, using MRI technique. Therefore the combination of MRI with optical imaging was focused to exquisite anatomical information, spatial resolution, and ability for functional information on a molecular level.
In this study, we designed multi-modal imaging probe based on superparamagnetic iron oxide nanoparticles and near infrared fluorophores. The multi modal imaging probe was shown distinguished optical and magnetic resonance imaging in vivo.
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