Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning

Title
Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning
Authors
Lenora Volk김종현Kogo TakamiayYilin YuRichard L. Huganir
Keywords
PICK1; LTP; LTD; Learning; Memory; Development; Synaptic Plasticity
Issue Date
2010-12
Publisher
Proceedings of the National Academy of Sciences of the United States of America
Citation
VOL 107, NO 50, 21784-21789
Abstract
AMPA-type glutamate receptors (AMPARs) mediate the majority of fast excitatory neurotransmission in the mammalian central nervous system. Modulation of AMPAR trafficking supports several forms of synaptic plasticity thought to underlie learning and memory. Protein interacting with C kinase 1 (PICK1) is an AMPAR-binding protein shown to regulate both AMPAR trafficking and synaptic plasticity at many distinct synapses. However, studies examining the requirement for PICK1 in maintaining basal synaptic transmission and regulating synaptic plasticity at hippocampal Schaffer collateral–cornu ammonis 1 (SC–CA1) synapses have produced conflicting results. In addition, the effect of PICK1 manipulation on learning andmemory has not been investigated. In the present study weanalyzed the effect of genetic deletion of PICK1 on basal synaptic transmission and synaptic plasticity at hippocampal Schaffer collateral– CA1 synapses in adult and juvenile mice. Surprisingly, we find that loss of PICK1 has no significant effect on synaptic plasticity in juvenile mice but impairs some forms of long-term potentiation and multiple distinct forms of long-term depression in adult mice. Moreover, inhibitory avoidance learning is impaired only in adultKOmice. These results suggest that PICK1 is selectively required for hippocampal synaptic plasticity and learning in adult rodents.
URI
http://pubs.kist.re.kr/handle/201004/38983
ISSN
0027-8424
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KIST Publication > Article
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