Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning
- Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning
- Lenora Volk; 김종현; Kogo Takamiay; Yilin Yu; Richard L. Huganir
- PICK1; LTP; LTD; Learning; Memory; Development; Synaptic Plasticity
- Issue Date
- Proceedings of the National Academy of Sciences of the United States of America
- VOL 107, NO 50, 21784-21789
- AMPA-type glutamate receptors (AMPARs) mediate the majority of
fast excitatory neurotransmission in the mammalian central nervous
system. Modulation of AMPAR trafficking supports several
forms of synaptic plasticity thought to underlie learning and memory.
Protein interacting with C kinase 1 (PICK1) is an AMPAR-binding
protein shown to regulate both AMPAR trafficking and synaptic
plasticity at many distinct synapses. However, studies examining
the requirement for PICK1 in maintaining basal synaptic transmission
and regulating synaptic plasticity at hippocampal Schaffer
collateral–cornu ammonis 1 (SC–CA1) synapses have produced conflicting
results. In addition, the effect of PICK1 manipulation on
learning andmemory has not been investigated. In the present study
weanalyzed the effect of genetic deletion of PICK1 on basal synaptic
transmission and synaptic plasticity at hippocampal Schaffer collateral–
CA1 synapses in adult and juvenile mice. Surprisingly, we find
that loss of PICK1 has no significant effect on synaptic plasticity in
juvenile mice but impairs some forms of long-term potentiation and
multiple distinct forms of long-term depression in adult mice. Moreover,
inhibitory avoidance learning is impaired only in adultKOmice.
These results suggest that PICK1 is selectively required for hippocampal
synaptic plasticity and learning in adult rodents.
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