Endothelial cells adhesion and growth on smooth muscle cell-derived ECM

Title
Endothelial cells adhesion and growth on smooth muscle cell-derived ECM
Authors
이양기한동근신흥수박귀덕
Keywords
Endothelial cells; smooth muscle cell; ECM
Issue Date
2010-11
Publisher
2010년 한국생체재료학회 제18차 학술대회
Citation
, 115-115
Abstract
Coronary atery disease (CAD) is recognized a major health threat worldwide, because of the need of immediate intervention and its high fatality. Currently the most dependable therapeutic approach is to use stent. However once vascular stent is implanted, vascular endothelial cell are often injured and smooth muscle cells (SMCs) are overgrowing toward the lumen of blood vessel. That causes thrombosis and neointimal hyperplasia. This phenomenon can be prevented if the stent surface was covered by endothelial cells (ECs). Our hypothesis is that a native extracellualr matrix (ECM) environment may provide a favorable microenvironment for ECs on the surface of stent. Using SMCs-derived matrix, ECs adhesion and proliferation were investigated.
URI
http://pubs.kist.re.kr/handle/201004/39027
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KIST Publication > Conference Paper
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