Thermosensitive Polyphosphazene-Anticancer Drug Conjugates: Locally Injectable and Controlled Delivery of Cancer Therapeutics

Title
Thermosensitive Polyphosphazene-Anticancer Drug Conjugates: Locally Injectable and Controlled Delivery of Cancer Therapeutics
Authors
전창주이선미김장원홍기연양한광김상윤송수창
Issue Date
2010-07
Publisher
37th Meeting & Exposition of the Controlled Release Society
Abstract
Poly(organophosphazene)-anticancer drug conjugate was synthesized to create a drug delivery system, which is based on locally injectable, biodegradable, and thermosensitive hydrogels. The aqueous solution of the polymer-drug conjugate showed a sol-gel transition behavior depending on temperature changes. The conjugate hydrogel after the local injection at the tumor site showed to inhibit tumor growth more effectively with less toxicity and much longer than controls, indicating that tumor active drug from the conjugate hydrogel is released slowly over a longer period of time and effectively accumulated locally in the tumor sites. It may be possible to develop a drug delivery system that can locally delivery the drug through an intratumoral injection, which does not require surgical surgery, to maximize tumor inhibition at the tumor sites over a prolonged period and to minimize the systemic side effects by the localization of polymer-drug conjugates.
URI
http://pubs.kist.re.kr/handle/201004/39198
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KIST Publication > Conference Paper
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