In Vivo Long-term Monitorial Magnetic Resonance Imaging and Therapy System for Solid Tumors Using Intratumoral Administration of Theragnostic Substances
- In Vivo Long-term Monitorial Magnetic Resonance Imaging and Therapy System for Solid Tumors Using Intratumoral Administration of Theragnostic Substances
- 김장일; 이범석; 전창주; 조정교; 김기철; 김상윤; 송수창
- Issue Date
- 37th Annual Meeting & Exposition of the Controlled Release Society
- An in vivo long-term monitorial MR imaging and therapy system was estimated over 3-week period based on the localization technology of theragnostic substances containing thermosensitive poly(organophosphazene) hydrogel, paclitaxel (PTX), and cobalt ferrite nanoparticle as a localizable platform, an anticancer drug, and an MR contrast agent, respectively. The theragnostic substances were also testified by both in vitro and in vivo toxicity estimations. In in vivo long-term anticancer therapy, the tumor growth was significantly inhibited by sustained-release anticancer drug. Meanwhile, in in vivo long-term monitorial MR imaging, the remarkable MR images regarding the progress of tumor growth and theragnostic substances within intratumoral site as the long-term monitorial system could be obtained.
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