Inhibitory effects of dicaffeoylquinic acids from Artemisia dubia on aldo-keto reductase family 1B10

Title
Inhibitory effects of dicaffeoylquinic acids from Artemisia dubia on aldo-keto reductase family 1B10
Authors
이희주이주영김상민노주원정상훈송대근김철영판철호
Keywords
AKR1B10; aldose reductase-like; anticancer; DCQA; dicaffeoylquinic acid; Artemisia dubia
Issue Date
2010-12
Publisher
한국응용생명화학회지; JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
Citation
VOL 53, NO 6, 826-830
Abstract
The ethyl acetate fraction of Artemisia dubia showed a potent inhibitory activity on recombinant human AKR1B10 (rh AKR1B10). Due to its potency, subsequent purification of ethyl acetate fraction led to seven compounds including five dicaffeoylquinic acid (DCQA) derivatives. Compounds were identified as 3,4-dihydroxybenzoic acid (1), quercetin 3-O-β-glucose (2), 3,4- DCQA (3), 3,5-DCQA (4), 4,5-DCQA (5), 3,5-DCQA methyl ester (6), and 4,5-DCQA methyl ester (7). A series of DCQA derivatives (3-7) showed inhibitory activity on rhAKR1B10 in the range of IC50 1.24-2.29 μM, whereas 3,4-dihydroxybenzoic acid and quercetin 3-O-β-glucose showed no inhibitory activity on rhAKR1B10.
URI
http://pubs.kist.re.kr/handle/201004/39224
ISSN
1738-2203
Appears in Collections:
KIST Publication > Article
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