Lateral Displacement and Conformation of DNA Chains in Abrupt 90 ˚ Microbends

Title
Lateral Displacement and Conformation of DNA Chains in Abrupt 90 ˚ Microbends
Authors
이정용정현욱현재천전명석
Keywords
λ-DNA molecule; Brownian dynamics; Microbends; Migration; Conformation
Issue Date
2011-01
Publisher
Journal of the Korean Physical Society
Citation
VOL 58, NO 1, 125-131
Abstract
The migration and conformation of a single λ-DNA chain in a microchannel with a 90 bend have been investigated using the hybrid numerical scheme of Brownian dynamics (BD) simulations and a CFD (computational fluid dynamics) solver, Flow-3D. A significant displacement of the single DNA chain was found after it had passed through the microbend and depended on its initial location. The λ-DNA chain initially positioned near the inner (or outer) wall migrated farther toward the inner (or outer) wall after passage through the bend. This is ascribed by the hydrodynamic features of the bulk flow field in the bend region. The relationship between an extension of the single chain and the flow characteristics was elucidated by changing the effective shear rate and the channel width.
URI
http://pubs.kist.re.kr/handle/201004/39332
ISSN
0374-4884
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE