Lateral Displacement and Conformation of DNA Chains in Abrupt 90 ˚ Microbends
- Lateral Displacement and Conformation of DNA Chains in Abrupt 90 ˚ Microbends
- 이정용; 정현욱; 현재천; 전명석
- λ-DNA molecule; Brownian dynamics; Microbends; Migration; Conformation
- Issue Date
- Journal of the Korean Physical Society
- VOL 58, NO 1, 125-131
- The migration and conformation of a single λ-DNA chain in a microchannel with a 90 bend have
been investigated using the hybrid numerical scheme of Brownian dynamics (BD) simulations and a
CFD (computational fluid dynamics) solver, Flow-3D. A significant displacement of the single DNA
chain was found after it had passed through the microbend and depended on its initial location.
The λ-DNA chain initially positioned near the inner (or outer) wall migrated farther toward the
inner (or outer) wall after passage through the bend. This is ascribed by the hydrodynamic features
of the bulk flow field in the bend region. The relationship between an extension of the single chain
and the flow characteristics was elucidated by changing the effective shear rate and the channel width.
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