Upper Body Motion Tracking With Inertial Sensors
- Upper Body Motion Tracking With Inertial Sensors
- 정유진; 강동훈; 김진욱
- motion tracking; inertial sensors; joints; kinematics; motion capture
- Issue Date
- In order to increase stability of quercetin, its metabolically and chemically susceptible hydroxyl groups
7-OH and 3-OH respectively were transiently blocked with a pivaloxymethyl (POM) promoiety to provide
two novel quercetin conjugates [7-O-POM-Q (2), 3-O-POM-Q (3)]. In the absence of stabilizer
(ascorbic acid), the synthesized conjugates showed significantly increased stability in cell culture media
[t1/2=4h (2), 52 h (3)] compared with quercetin (t1/2<30 min) and quercetin prodrug 1 (t1/2=0.8 h). In
addition, the quercetin conjugate 2 underwent efficient cellular uptake and intracellular levels of its
hydrolysis product, quercetin, were maintained up to 12 h. Stability and intracellular accumulation of 2
were demonstrated by its stabilizer-independent cytostatic effect and induction of apoptotic cell death.
Even though 3 was more stable than 2, it failed to penetrate cell membranes. However, the remarkable
stability of 3 warrants further investigation of quercetin conjugates with various promoieties at the
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