Upper Body Motion Tracking With Inertial Sensors

Title
Upper Body Motion Tracking With Inertial Sensors
Authors
정유진강동훈김진욱
Keywords
motion tracking; inertial sensors; joints; kinematics; motion capture
Issue Date
2010-12
Publisher
ROBIO2010
Abstract
In order to increase stability of quercetin, its metabolically and chemically susceptible hydroxyl groups 7-OH and 3-OH respectively were transiently blocked with a pivaloxymethyl (POM) promoiety to provide two novel quercetin conjugates [7-O-POM-Q (2), 3-O-POM-Q (3)]. In the absence of stabilizer (ascorbic acid), the synthesized conjugates showed significantly increased stability in cell culture media [t1/2=4h (2), 52 h (3)] compared with quercetin (t1/2<30 min) and quercetin prodrug 1 (t1/2=0.8 h). In addition, the quercetin conjugate 2 underwent efficient cellular uptake and intracellular levels of its hydrolysis product, quercetin, were maintained up to 12 h. Stability and intracellular accumulation of 2 were demonstrated by its stabilizer-independent cytostatic effect and induction of apoptotic cell death. Even though 3 was more stable than 2, it failed to penetrate cell membranes. However, the remarkable stability of 3 warrants further investigation of quercetin conjugates with various promoieties at the 3-OH position.
URI
http://pubs.kist.re.kr/handle/201004/39338
Appears in Collections:
KIST Publication > Conference Paper
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