Heavy-Atomic Construction of Photosensitizer Nanoparticles for Enhanced Photodynamic Therapy of Cancer

Title
Heavy-Atomic Construction of Photosensitizer Nanoparticles for Enhanced Photodynamic Therapy of Cancer
Authors
임창근신지영이용덕김정안박호용권익찬김세훈
Issue Date
2011-01
Publisher
Small
Citation
VOL 7, NO 1, 112-118
Abstract
A new type of heavy-atom-affected Pluronic (F-127) nanoparticle (FIC NP) for photodynamic therapy (PDT) is reported. FIC NPs are formulated with biocompatible constituents, and contain densely integrated iodinated aromatic molecules that form a structurally rigid core matrix and stably encapsulate photosensitizers in a monomeric form. Tiny nanoparticles ( ≈ 10 nm) are prepared by aqueous dispersion of photosensitizer-embedded aromatic nanodomains, which self-assemble by phase separation from the Pluronic melt mixture. By using spectroscopic studies and cellular experiments, the following is demonstrated: 1) enhanced singlet-oxygen generation by means of the intraparticle heavy-atom effect on the embedded photosensitizer, 2) facilitated cell uptake due to the small nanoscopic size as well as the Pluronic surface characteristics, and thereby 3) actual enhancement of PDT effi cacy for a human breast-cancer cell line (MDA-MB-231), which validates a photophysically motivated nanoformulation approach toward an advanced photosensitizing nanomedicine.
URI
http://pubs.kist.re.kr/handle/201004/39347
ISSN
1613-6810
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KIST Publication > Article
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