Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers

Title
Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers
Authors
최연희백두종서선희이재균배애님조용서민선준
Keywords
T-Type calcium channel blockers; Meldrum’s acid; 3,3-Diphenylpropanoyl piperazine; HTS assays
Issue Date
2011-01
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 21, NO 1, 215-219
Abstract
We have developed a facile synthesis of 3,3-diphenylpropanamides using Meldrum’s acid derivatives as amide coupling components. The in vitro biological evaluation of the title compounds led to the identification of compound 1h, which has good inhibitory activity against T-type calcium channel (IC50 = 0.83 μM).
URI
http://pubs.kist.re.kr/handle/201004/39372
ISSN
0960-894X
Appears in Collections:
KIST Publication > Article
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