Accelerating fluorescent sensor discovery: unbiased screening of a diversity-oriented BODIPY library

Title
Accelerating fluorescent sensor discovery: unbiased screening of a diversity-oriented BODIPY library
Authors
이준석김형규Suihan FengMarc Vendrell장영태
Keywords
fluorescent; probe; BODIPY
Issue Date
2011-02
Publisher
Chemical communications
Citation
VOL 47, NO 8, 2339-2341
Abstract
In summary, we have systematically examined the fluorescence response of a diversity-oriented BODIPY library (BD) using an unbiased in vitro screening strategy. Based on the quantum yield changes against a variety of biomolecules, we could infer general trends of the BODIPY fluorescence response pattern, and discover two novel fluorescent probes: BD-101 behaved as a turn-on sensor for BSA, while BD-187 showed a remarkable fluorescence quenching upon interaction with dopamine. With this first unbiased screening of the fluorescence pattern of the BODIPY structure, we demonstrated the power and broad applicability of this approach for accelerating fluorescent sensor discovery, without prior implementation of a pre-established binding motif in the fluorophore structure.
URI
http://pubs.kist.re.kr/handle/201004/39420
ISSN
1359-7345
Appears in Collections:
KIST Publication > Article
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