Comparison of diamond-like carbon-coated nitinol stents with or without polyethylene glycol grafting and uncoated nitinol stents in a canine iliac artery model

Title
Comparison of diamond-like carbon-coated nitinol stents with or without polyethylene glycol grafting and uncoated nitinol stents in a canine iliac artery model
Authors
김지형신지훈신동호문명운박귀덕김태형신경민원유형한동근이광렬
Keywords
DLC; hemocompatibility; vascular stent; in vivo test
Issue Date
2011-03
Publisher
The British journal of radiology
Citation
VOL 84, 210-215
Abstract
Objective: Neointimal hyperplasia is a major complication of endovascular stent placement with consequent in-stent restenosis or occlusion. Improvements in the biocompatibility of stent designs could reduce stent-associated thrombosis and in-stent restenosis. We hypothesised that the use of a diamond-like carbon (DLC)-coated nitinol stent or a polyethylene glycol (PEG)-DLC-coated nitinol stent could reduce the formation of neointimal hyperplasia, thereby improving stent patency with improved biocompatibility. Methods: A total of 24 stents were implanted, under general anaesthesia, into the iliac arteries of six dogs (four stents in each dog) using the carotid artery approach. The experimental study dogs were divided into three groups: the uncoated nitinol stent group (n58), the DLC-nitinol stent group (n58) and the PEG-DLC-nitinol stent group (n58). Results: The mean percentage of neointimal hyperplasia was significantly less in the DLC-nitinol stent group (26.7¡7.6%) than in the nitinol stent group (40.0¡20.3%) (p50.021). However, the mean percentage of neointimal hyperplasia was significantly greater in the PEG-DLC-nitinol stent group (58.7¡24.7%) than in the nitinol stent group (40.0¡20.3%) (p50.01). Conclusion: Our findings indicate that DLC-coated nitinol stents might induce less neointimal hyperplasia than conventional nitinol stents following implantation in a canine iliac artery model; however, the DLC-coated nitinol stent surface when reformed with PEG induces more neointimal hyperplasia than either a conventional or DLCcoated nitinol stent.
URI
http://pubs.kist.re.kr/handle/201004/39434
ISSN
0007-1285
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KIST Publication > Article
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