Small Diameter Double Layer Tubular Scaffolds Using Highly Elastic PLCL Copolymer for Vascular Tissue Engineering

Title
Small Diameter Double Layer Tubular Scaffolds Using Highly Elastic PLCL Copolymer for Vascular Tissue Engineering
Authors
카비따김상훈박인수이선희김수희정영미김상헌김수현
Keywords
poly(L-lactide-co-ε-caprolactone); gel spinning; small diameter vascular scaffolds; ePTFE grafts; tensile test
Issue Date
2011-02
Publisher
Macromolecular research
Citation
VOL 19, NO 2, 122-129
Abstract
Tubular double layered scaffolds were fabricated using a biodegradable and elastic polymer, poly(L-lactide- co-ε-caprolactone) (PLCL, 50:50), which was comprised of an outer fibrous gel spun layer and inner porous dip coated layer. The mechanical properties were evaluated and compared with a rabbit aorta and expanded poly-tetrafluoroethylene (ePTFE). The PLCL scaffolds had circumferentially stronger tensile stress than the rabbit aorta and ePTFE graft, and its longitudinal stress was similar to a rabbit aorta but weaker than ePTFE. The E-modulus of the PLCL scaffold was significantly lower than that of ePTFE but significantly higher than that of the native rabbit aorta, this result was reversible in the case of compliance. There was no significant difference in suture retention strength and burst pressure compared to ePTFE grafts. The scaffolds were seeded with SMCs and cultured under dynamic conditions for 13 days to evaluate the cellularity. After a 13 day dynamic culture, the scaffolds showed efficient cell proliferation. Overall, the double layer small diameter PLCL scaffolds exhibited favorable mechanical strength even at a high pressure and good cellularity under dynamic conditions.
URI
http://pubs.kist.re.kr/handle/201004/39469
ISSN
1598-5032
Appears in Collections:
KIST Publication > Article
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