Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques

Title
Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques
Authors
최기현송치만정찬성임혜원
Keywords
T-type calcium channel; Cav3.1; Automated patch-clamp; Drug discovery
Issue Date
2011-03
Publisher
General physiology and biophysics
Citation
VOL 30, 100-105
Abstract
T-type calcium channels are involved in a variety of physiological and pathophysiological processes, and thus could be therapeutic targets. However, there is no T-type channel selective blocker for use in clinical practice, demanding a need for the development of novel drugs where a higher-throughput screening system is required. Here we present pharmacological studies on Cav3.1 T-type channels using automated patch-clamp. The IC50 values obtained from automated patch-clamp and conventional one showed a good correlation (correlation coefficient of 0.82), suggesting that the automated patch-clamp is an efficient and reliable method for ranking the drug potencies for T-type channels.
URI
http://pubs.kist.re.kr/handle/201004/39494
ISSN
0231-5882
Appears in Collections:
KIST Publication > Article
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