Manipulating the Power of an Additional Phase: A Flower-like Au-Fe3O4 Optical Nanosensor for Imaging Protease Expressions In vivo
- Manipulating the Power of an Additional Phase: A Flower-like Au-Fe3O4 Optical Nanosensor for Imaging Protease Expressions In vivo
- Jin Xie; Fan Zhang; Maria Aronova; Lei Zhu; Xin Lin; Qimeng Quan; Gang Liu; Guofeng Zhang; 최기영; 김광명; Xiaolian Sun; 이슬기; Shouheng Sun; Richard Leapman; Xiaoyuan Chen
- composite nanoparticles; Au-Fe3O4; matrix metalloproteinase; activatable probes; near-infrared fluorescence imaging
- Issue Date
- ACS Nano
- VOL 5, NO 4, 3043-3051
- We and others have recently proposed the synthesis of composite nanoparticles that
offer strongly enhanced functionality. Here we have used a flower-shaped Au-Fe3O4 nanoparticle
as a template to construct an optical probe containing Cy5.5-GPLGVRG-TDOPA on the iron oxide
surface and SH-PEG5000 on the gold surface that can be specifically activated by matrix
metalloproteinases expressed in tumors. Gold nanoparticles have excellent quenching properties,
but labile surface chemistry in vivo; on the other hand, iron oxide nanoparticles afford robust surface
chemistry, but are suboptimal as energy receptors. By a marriage of the two, we have produced a
unified structure with performance that is unachievable with the separate components. Our results
are a further demonstration that the architecture of nanoparticles can be modulated to tailor their
function as molecular imaging/therapeutic agents.
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