Manipulating the Power of an Additional Phase: A Flower-like Au-Fe3O4 Optical Nanosensor for Imaging Protease Expressions In vivo

Title
Manipulating the Power of an Additional Phase: A Flower-like Au-Fe3O4 Optical Nanosensor for Imaging Protease Expressions In vivo
Authors
Jin XieFan ZhangMaria AronovaLei ZhuXin LinQimeng QuanGang LiuGuofeng Zhang최기영김광명Xiaolian Sun이슬기Shouheng SunRichard LeapmanXiaoyuan Chen
Keywords
composite nanoparticles; Au-Fe3O4; matrix metalloproteinase; activatable probes; near-infrared fluorescence imaging
Issue Date
2011-04
Publisher
ACS Nano
Citation
VOL 5, NO 4, 3043-3051
Abstract
We and others have recently proposed the synthesis of composite nanoparticles that offer strongly enhanced functionality. Here we have used a flower-shaped Au-Fe3O4 nanoparticle as a template to construct an optical probe containing Cy5.5-GPLGVRG-TDOPA on the iron oxide surface and SH-PEG5000 on the gold surface that can be specifically activated by matrix metalloproteinases expressed in tumors. Gold nanoparticles have excellent quenching properties, but labile surface chemistry in vivo; on the other hand, iron oxide nanoparticles afford robust surface chemistry, but are suboptimal as energy receptors. By a marriage of the two, we have produced a unified structure with performance that is unachievable with the separate components. Our results are a further demonstration that the architecture of nanoparticles can be modulated to tailor their function as molecular imaging/therapeutic agents.
URI
http://pubs.kist.re.kr/handle/201004/39552
ISSN
1936-0851
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE