Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque

Title
Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque
Authors
손수민박종호Matthias NahrendorfDawid Schellingerhou김정연강병택정상욱김요진류주희김광명권익찬이동건이명묵김동억
Keywords
Exercise; Atherosclerosis; Matrix metalloproteinase; Preexisting plaque; Molecular imaging
Issue Date
2011-05
Publisher
Atherosclerosis
Citation
VOL 216, NO 1, 67-73
Abstract
Objective : Few studies have investigated if exercise by itself has anti-atherosclerotic effects, without combining interventions with a low-fat diet. We studied the effects of exercise as a stand-alone intervention on preexisting atheromata by measuring not only plaque size but also the levels of plaque-destabilizing matrix-metalloproteinase (MMP) activity in vivo. Methods and results : We used near-infrared fluorescent (NIRF) molecular imaging with an MMP-2/9 activatable NIRF probe to visualize the inflammatory protease activity within preexisting atheromata of 17-week-old ApoE−/− mice on: (a) normal chow diet (NCD), (b) Western diet (WD), and (c) WD with treadmill exercise for 10 weeks. We also measured tissue levels of aortic lipid peroxidation (LPO) and plasma levels of glucose/lipid/cytokine profiles. Exercise did not attenuate growth of preexisting atheromatous plaques. However, exercise strongly decreased proteolytic activity in plaques for animals on WD, with levels decreasing almost to NCD levels. Exercise was associated with decreased aortic LPO levels and increased blood adiponectin/leptin levels; however, exercise did not affect WD-consumption/weight-gain or improve blood glucose/lipid profiles. Conclusions : Exercise training reduced aortic MMP activity in mice with preexisting atheromata, even though they remained on a high fat diet and plaque-growth was not attenuated.
URI
http://pubs.kist.re.kr/handle/201004/39553
ISSN
0021-9150
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KIST Publication > Article
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