Near-infrared fluorescence imaging using a protease-specific probe for the detection of colon tumors

Title
Near-infrared fluorescence imaging using a protease-specific probe for the detection of colon tumors
Authors
윤순만명성재예병덕김인화이남곤류연미박경순김광명권익찬박영수박찬식문대혁김도훈도미영변정식양석균김진호
Keywords
Colon cancer; Inflammatory bowel disease; Near-infrared fluorescence; Matrix metalloproteinases
Issue Date
2010-12
Publisher
GUT AND LIVER
Citation
VOL 4, NO 4, 488-497
Abstract
Results: Multiple variable- sized tumors developed in both models and progressed from adenomas to adenocarcinomas over time. At the early stage of the AOM/DSS model, diffuse inflammation was observed within the tumors. MMP expression increased progressively through normal, inflammation, adenoma, and adenocarcionoma stages. NIRF signal intensities were strongly correlated with each tumor stage from adenoma to adenocarcinoma. NIRF imaging also distinguished tumors from inflamed mucosa. Conclusions: NIRF imaging using a protease-activatable probe may be a useful tool for early tumor detection. This approach could translate to improve the endoscopic detection of colon tumors, especially in patients with inflammatory bowel disease.
URI
http://pubs.kist.re.kr/handle/201004/39555
ISSN
1976-2283
Appears in Collections:
KIST Publication > Article
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