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dc.contributor.author윤순만-
dc.contributor.author명성재-
dc.contributor.author예병덕-
dc.contributor.author김인화-
dc.contributor.author이남곤-
dc.contributor.author류연미-
dc.contributor.author박경순-
dc.contributor.author김광명-
dc.contributor.author권익찬-
dc.contributor.author박영수-
dc.contributor.author박찬식-
dc.contributor.author문대혁-
dc.contributor.author김도훈-
dc.contributor.author도미영-
dc.contributor.author변정식-
dc.contributor.author양석균-
dc.contributor.author김진호-
dc.date.accessioned2015-12-03T00:37:21Z-
dc.date.available2015-12-03T00:37:21Z-
dc.date.issued201012-
dc.identifier.citationVOL 4, NO 4, 488-497-
dc.identifier.issn1976-2283-
dc.identifier.other34699-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/39555-
dc.description.abstractResults: Multiple variable- sized tumors developed in both models and progressed from adenomas to adenocarcinomas over time. At the early stage of the AOM/DSS model, diffuse inflammation was observed within the tumors. MMP expression increased progressively through normal, inflammation, adenoma, and adenocarcionoma stages. NIRF signal intensities were strongly correlated with each tumor stage from adenoma to adenocarcinoma. NIRF imaging also distinguished tumors from inflamed mucosa. Conclusions: NIRF imaging using a protease-activatable probe may be a useful tool for early tumor detection. This approach could translate to improve the endoscopic detection of colon tumors, especially in patients with inflammatory bowel disease.-
dc.publisherGUT AND LIVER-
dc.subjectColon cancer-
dc.subjectInflammatory bowel disease-
dc.subjectNear-infrared fluorescence-
dc.subjectMatrix metalloproteinases-
dc.titleNear-infrared fluorescence imaging using a protease-specific probe for the detection of colon tumors-
dc.typeArticle-
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